abstract：:The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obt...

journal_title：International journal of pharmaceutics

authors： Karadağ E,Uzüm OB,Saraydin D,Güven O

更新日期：2005-09-14 00:00:00

abstract：:Microemulsion systems composed of Span20/80+Tween20/80+n-butanol+H2O+isopropyl palmitate (IPP)/isopropyl myristate (IPM) were investigated as model systems of drug carriers for eye drops. Effects of chloramphenicol, normal saline, sodium hyaluronate and various oils on the phase behavior were studied. The phase transi...

journal_title：International journal of pharmaceutics

authors： Lv FF,Zheng LQ,Tung CH

更新日期：2005-09-14 00:00:00

abstract：:Preparation of oil-in-water (o/w) type lipid emulsion is one of the approaches to formulate drugs that are poorly water-soluble but can be dissolved in the oil phase of the emulsions. A synthetic glucocorticoid medicine, difluprednate (DFBA), is a water-insoluble compound. We formulated DFBA (0.05%, w/v) ophthalmic li...

journal_title：International journal of pharmaceutics

authors： Yamaguchi M,Yasueda S,Isowaki A,Yamamoto M,Kimura M,Inada K,Ohtori A

更新日期：2005-09-14 00:00:00

abstract：:The main purpose of this study was to develop self-emulsifying drug delivery systems (SEDDS) for the improvement of the stability of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) after released from poly (D,L-lactide-co-glycolide) (PLGA) wafer and to evaluate its in vitro antitumor activity against 9L gliosarcoma cells....

journal_title：International journal of pharmaceutics

authors： Chae GS,Lee JS,Kim SH,Seo KS,Kim MS,Lee HB,Khang G

更新日期：2005-09-14 00:00:00

abstract：:Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

journal_title：International journal of pharmaceutics

authors： Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

更新日期：2005-08-26 00:00:00

abstract：:Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules. When medicines are not licensed for children, it is unlikely that there will be a suitable, licensed liquid formulation and so extemporaneous liquid preparations ...

journal_title：International journal of pharmaceutics

authors： Standing JF,Tuleu C

更新日期：2005-08-26 00:00:00

abstract：:The mechanical characteristics of non-ionic bilayer membranes composed of sorbitan monostearate, cholesterol and poly-24-oxyethylene cholesteryl were studied by measuring the modulus of surface elasticity (mu), a measure of membrane strength, as a function of cholesterol content and temperature. The modulus of surface...

journal_title：International journal of pharmaceutics

authors： Nasseri B

更新日期：2005-08-26 00:00:00

abstract：:Gamma-oryzanol, a phytosteryl ferulate mixture extracted from rice bran oil, has a wide spectrum of biological activities; in particular, it has antioxidant properties and is often used in cosmetic formulations as a sunscreen. The first objective of the present investigation was to elucidate the molecular mechanism(s)...

journal_title：International journal of pharmaceutics

authors： Juliano C,Cossu M,Alamanni MC,Piu L

更新日期：2005-08-11 00:00:00

abstract：:Titration calorimetry was used to investigate the interaction between a model antigen, bovine serum albumin (BSA), and a model particulate carrier, polystyrene (PS). The binding enthalpy was much higher than reported in the literature for a similar system and did not display a sigmoidal binding curve. These experiment...

journal_title：International journal of pharmaceutics

authors： Pollitt MJ,Buckton G,Brocchini S,Alpar HO

更新日期：2005-07-25 00:00:00

abstract：:The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate...

journal_title：International journal of pharmaceutics

authors： Ljusberg-Wahren H,Seier Nielsen F,Brogård M,Troedsson E,Müllertz A

更新日期：2005-07-25 00:00:00

abstract：:Combining the Rayleigh-type jet break-up and two new plate nozzles, the alginate microsphere was produced. Spray generators made of syringe needle and laser-drilling nozzle plate and synthetic red stone nozzle plate were fabricated and contrasted. The above two plate nozzles provided lower liquid resistance and yield ...

journal_title：International journal of pharmaceutics

authors： Yang F,Wang K,He Z

更新日期：2005-07-14 00:00:00

abstract：:Lipid nanoparticles (LNP) based on triglycerides containing high amounts of the amphiphilic lipid lecithin have been proposed as a promising alternative drug delivery system with regard to drug loading capacity. Aim of the present study is to evaluate the influence of lecithin within the lipid matrix (LM) on the cryst...

journal_title：International journal of pharmaceutics

authors： Schubert MA,Schicke BC,Müller-Goymann CC

更新日期：2005-07-14 00:00:00

abstract：:Plasma stability plays an important role in drug discovery and development. Unstable compounds tend to have rapid clearance and short half-life, resulting in poor in vivo performance. This paper examines the variables that affect the plasma stability assay results, including substrate concentration, %DMSO, plasma conc...

journal_title：International journal of pharmaceutics

authors： Di L,Kerns EH,Hong Y,Chen H

更新日期：2005-06-13 00:00:00

abstract：:The objective of this study was to design an all-trans retinoic acid (RA) topical release system that modifies drug diffusion parameters in the vehicle and the skin in order to reduce systemic absorption and the side-effects associated with topical application of the drug to skin. Three cases of application of hydroge...

journal_title：International journal of pharmaceutics

authors： Fresno Contreras MJ,Jiménez Soriano MM,Ramírez Diéguez A

更新日期：2005-06-13 00:00:00

abstract：:Directly compressed theophylline tablets, containing commercial xanthan (X) (Keltrol) and a highly hydrophilic galactomannan (G) from the seeds of Mimosa scabrella (a brazilian leguminous tree called bracatinga) as release-controlling agents, were obtained. Gums were used at 4, 8, 12.5 and 25% (w/w), either alone or i...

journal_title：International journal of pharmaceutics

authors： Vendruscolo CW,Andreazza IF,Ganter JL,Ferrero C,Bresolin TM

更新日期：2005-05-30 00:00:00

abstract：:Little is known about chronopharmacokinetics of PDE V inhibitors in rats as well as in humans. Hence, the pharmacokinetics of DA-8159 and one of its metabolites, DA-8164, were investigated after intravenous and oral administration of DA-8159 at a dose of 30 mg/kg administered at 10:00 h versus 22:00 h in rats. After i...

journal_title：International journal of pharmaceutics

authors： Lee JH,Kim YC,Kwon JW,Kim WB,Lee MG

更新日期：2005-05-30 00:00:00

abstract：:Hydrotalcite is a biocompatible lamellar anionic clay formed by double hydroxide layers with a metal cation coordinating four OH groups. The different layers are held together by anionic hosts that can be replaced by a simple ion-exchange process. The synthetic Mg-Al-hydrotalcite was used to intercalate ferulic acid, ...

journal_title：International journal of pharmaceutics

authors： Rossi C,Schoubben A,Ricci M,Perioli L,Ambrogi V,Latterini L,Aloisi GG,Rossi A

更新日期：2005-05-13 00:00:00

abstract：:Praziquantel (PZQ) is effective against all known species of Schistosomes that infect humans. The failure of mass treatment of schistosomiasis has been attributed to the fact that therapy is not sufficiently long-lasting. This effect may be due to the low bioavailability of PZQ that has a low hydrosolubility and fast ...

journal_title：International journal of pharmaceutics

authors： Mourão SC,Costa PI,Salgado HR,Gremião MP

更新日期：2005-05-13 00:00:00

abstract：:Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinit...

journal_title：International journal of pharmaceutics

authors： Souto EB,Anselmi C,Centini M,Müller RH

更新日期：2005-05-13 00:00:00

abstract：:Genetic immunization through skin is highly desirable as skin has plenty of antigen presenting cells (APCs) and is easily accessible. The purpose of this study was to investigate the effects of electroporation pulse amplitude, pulse length and number of pulses on cutaneous plasmid DNA vaccine delivery and immune respo...

journal_title：International journal of pharmaceutics

authors： Medi BM,Hoselton S,Marepalli RB,Singh J

更新日期：2005-04-27 00:00:00

abstract：:A wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concer...

journal_title：International journal of pharmaceutics

authors： Han J,Beeton A,Long P,Karimova A,Robertson A,Cross N,Smith L,O'Callaghan M,Goldman A,Brown K,Tuleu C

更新日期：2005-04-27 00:00:00

abstract：:An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matri...

journal_title：International journal of pharmaceutics

authors： McCarron PA,Donnelly RF,Zawislak A,Woolfson AD,Price JH,McClelland R

更新日期：2005-04-11 00:00:00

abstract：:In general, absorption enhancing effects of various absorption enhancers were greater in the large intestine than those in the small intestinal regions. Therefore, the effectiveness of absorption enhancers is expected to be remarkably observed, if these enhancers can be delivered to the large intestine with some poorl...

journal_title：International journal of pharmaceutics

authors： Fetih G,Lindberg S,Itoh K,Okada N,Fujita T,Habib F,Artersson P,Attia M,Yamamoto A

更新日期：2005-04-11 00:00:00

abstract：:In the present work, the Hot Air Coating (HAC) technique was used to prepare microparticulate systems containing nifedipine. Binary mixtures constituting of nifedipine and cetearyl alcohol (CA) in different proportions (30:70, 50:50, 70:30) were studied: they were homogenized by mixing or milling before spray treatmen...

journal_title：International journal of pharmaceutics

authors： Giovannelli L,Bellomi S,Pattarino F,Albertini B

更新日期：2005-04-11 00:00:00

abstract：:The USP tablet dissolution test is an analytical tool used for the verification of drug release processes and formulation selection within the pharmaceutical industry. Given the strong impact of this test, it is surprising that operating conditions and testing devices have been selected empirically. In fact, the flow ...

journal_title：International journal of pharmaceutics

authors： Baxter JL,Kukura J,Muzzio FJ

更新日期：2005-03-23 00:00:00

abstract：:A co-polymer of poly(N-isopropylacrylamide) (85%) co-butyl acrylate (10%) co-methacrylic acid (5%) (NIPAM/BA/MAA) (85/10/5) microgel was synthesised and investigated as a potential pH and temperature sensitive transdermal delivery device. Three compounds having different octanol/water partition coefficients and solubi...

journal_title：International journal of pharmaceutics

authors： Lopez VC,Hadgraft J,Snowden MJ

更新日期：2005-03-23 00:00:00

abstract：:Hybrid liposomes can be prepared by simply ultrasonicating a mixture of vesicular and micellar molecules in aqueous solution. A clear solution of hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(23)dodecyl ether (C12(EO)23) having a hydrodynamic diameter of 100-120...

journal_title：International journal of pharmaceutics

authors： Iwamoto Y,Matsumoto Y,Ueoka R

更新日期：2005-03-23 00:00:00

abstract：:The aim of our research was to apply experimental design methodology in the development and optimization of drug release methods. Diclofenac sodium (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid monosodium salt) was selected as a model drug and Naklofen retard prolonged release tablets, containing 100 mg of diclofen...

journal_title：International journal of pharmaceutics

authors： Kincl M,Turk S,Vrecer F

更新日期：2005-03-03 00:00:00

abstract：:Three innovative components (an annular gap spray system, a booster bottom and an outlet filter) have been developed by Innojet Technologies to improve fluid bed technology and to reduce the common interference factors (clogging of nozzles and outlet filters, spray loss, spray drying and fluidized bed heterogeneity). ...

journal_title：International journal of pharmaceutics

authors： Behzadi SS,Klocker J,Hüttlin H,Wolschann P,Viernstein H

更新日期：2005-03-03 00:00:00

abstract：:Conventional lipid microspheres (LM) were prepared using soybean oil and lipid at a 5.5:1 weight ratio with lipid phase consisting of PC (phosphatidyl choline):CH (cholesterol) (1:0.5) by molar ratio. The average diameter of the particles was 150 nm. Long-circulating microspheres (S-LM) were also prepared similarly bu...

journal_title：International journal of pharmaceutics

authors： Palakurthi S,Vyas SP,Diwan PV

更新日期：2005-02-16 00:00:00

abstract：:The aim of this study was to examine the diffusion of commonly administered analgesics, ibuprofen and paracetamol, through gastric mucus. As ibuprofen and paracetamol are often formulated with alkalising excipients, or are commonly co-administered with antacids that have been demonstrated to alter their absorption, di...

journal_title：International journal of pharmaceutics

authors： Shaw LR,Irwin WJ,Grattan TJ,Conway BR

更新日期：2005-02-16 00:00:00

abstract：:Lansoprazole (LPZ) is a representative drug that shows a high inter-subject variation of bioavailability (BA). Solid preparation composed of surfactant, adsorbent and LPZ were prepared to improve the dissolution and absorption of LPZ, and the BA of LPZ was measured in rats and dogs. As surfactant, Tween 80, polyoxy 60...

journal_title：International journal of pharmaceutics

authors： Ito Y,Arai H,Uchino K,Iwasaki K,Shibata N,Takada K

更新日期：2005-01-31 00:00:00

abstract：:Ciclopirox olamine (CPO) metal complexes have been prepared and characterized using elemental analysis, infra red (IR), melting point and differential scanning calorimetry (DSC). Spectroscopic titration using molar ratio method indicated the occurrence of 1:1 complexes for CPO with almost all the examined metals. Phys...

journal_title：International journal of pharmaceutics

authors： Tarawneh RT,Hamdan II,Bani-Jaber A,Darwish RM

更新日期：2005-01-31 00:00:00

abstract：:The purpose of this study was to synthesize and characterize biodegradable and thermosensitive triblock copolymers for delivering protein at controlled rate in biologically active form for longer duration of time. A series of thermosensitive triblock copolymers with different block lengths (PLGA-PEG-PLGA) were synthes...

journal_title：International journal of pharmaceutics

authors： Chen S,Pieper R,Webster DC,Singh J

更新日期：2005-01-20 00:00:00

abstract：:Mucoadhesive microspheres were prepared to increase gastric residence time using an interpolymer complexation of poly(acrylic acid) (PAA) with poly(vinyl pyrrolidone) (PVP) and a solvent diffusion method. The complexation between poly(acrylic acid) and poly(vinyl pyrrolidone) as a result of hydrogen bonding was confir...

journal_title：International journal of pharmaceutics

authors： Chun MK,Cho CS,Choi HK

更新日期：2005-01-20 00:00:00

abstract：:Fluconazole is an antifungal agent. The purpose of this study was to evaluate bioequivalence of two commercial 150 mg capsule formulations of fluconazole available in the Brazilian market. The study was an open, randomized, two-period, two-group crossover trial with a 2-week washout interval. Blood samples were collec...

journal_title：International journal of pharmaceutics

authors： Porta V,Chang KH,Storpirtis S

更新日期：2005-01-06 00:00:00

abstract：:The principal component of aqueous extract of jelly fig (Ficus awkeotsang Makino) seeds is a pectin-type polysaccharide, gelling even at room temperature without adding any sugars, acids or ions. The objective of this study was to evaluate jelly fig extract (JF) as a matrix base for sustained release tablets. Drug rel...

journal_title：International journal of pharmaceutics

authors： Miyazaki Y,Yakou S,Takayama K

更新日期：2004-12-09 00:00:00

abstract：:Proquazone, a poorly wettable compound, was used as a model drug in the search for reasons to develop a capsule or tablet formulation. The capsules were filled with proquazone as active ingredient, with lactose monohydrate (200 mesh) as filler and with magnesium stearate as lubricant. The tablet was made out of a gran...

journal_title：International journal of pharmaceutics

authors： von Orelli J,Leuenberger H

更新日期：2004-12-09 00:00:00

abstract：:Twenty diclofenac sodium buccoadhesive discs containing Cp974p, polycarbophil, PEO, SCMC-medium viscosity (SCMC-MV), SCMC-ultrahigh viscosity (SCMC-UHV) or their combinations were prepared. These buccoadhesive discs were evaluated for release pattern, swelling capacity, surface pH, mucoadhesion performance, and in vit...

journal_title：International journal of pharmaceutics

authors： El-Samaligy MS,Yahia SA,Basalious EB

更新日期：2004-11-22 00:00:00

abstract：:Hydrophobic porphyrins are potentially interesting molecules for the photodynamic therapy (PDT) of solid cancers or ocular vascularization diseases. Their pharmaceutical development is, however, hampered by their lipophilicity, which renders formulation difficult especially when intravenous administration is needed. E...

journal_title：International journal of pharmaceutics

authors： Vargas A,Pegaz B,Debefve E,Konan-Kouakou Y,Lange N,Ballini JP,van den Bergh H,Gurny R,Delie F

更新日期：2004-11-22 00:00:00